An archived version of the live presentation held on October 30th is now available. Click here to access.
Join us for the FoNIA’s Annual Science Advances meeting with NIA leadership on Friday, October 30th, from 1:00—3:30 pm ET.
Access the meeting via Webex . Meeting number (access code): 126 848 1720 Meeting password: 7Kpnm6JBMY4 or
Join by phone 1-650-479-3208 Call-in toll number (US/Canada)
For those who might be interested in submitting an application to RFA-CA-20-040 in which NIA is an equal partner, please see this notice.
Informational Webinar scheduled for Sep 18.
Questions ahead of Webinar due Sep 14.
The lead contact for NIA is Candace Kerr, Ph.D.
Email: [email protected]
Pre-Application Webinar for RFA-CA-20-040, Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed)
Notice Number: NOT-CA-20-105
Release Date: September 8, 2020
RFA-CA-20-040 – Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed)
Issued by National Cancer Institute (NCI)
The National Cancer Institute (NCI) will hold a pre-application webinar on September 18, 2020, from 1:00 – 2:00 PM (ET) for the Funding Opportunity Announcement (FOA) RFA-CA-20-040 titled “Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed)”.
NCI and National Institute on Aging (NIA) staff members involved in the FOA will provide a brief overview of the RFA-CA-20-040 for potential applicants by explaining the goals and objectives for the FOA, as well as answering questions from webinar attendees.
Please submit questions by September 14, 2020 to [email protected]. Attendees will also be able to submit questions during the webinar. Questions submitted early will be answered first.
Join the webinar or copy and paste the following Webex link into your browser: https://cbiit.webex.com/cbiit/j.php?MTID=m6a7b73daaa815f0601174dbebb02345c
Participation in this webinar, although encouraged, is optional and is not required for the submission of an application in response to RFA-CA-20-040. A document highlighting frequently asked questions and corresponding answers will be posted to the NCI Division of Cancer Biology FOA website following the webinar.
Please direct all inquiries to:
Margaret Klauzinska, Ph.D.
National Cancer Institute (NCI)
Email: [email protected]
Candace Kerr, Ph.D.
National Institute on Aging (NIA)
Email: [email protected]
Join us for the Open Session of the NIA Advisory Council Meeting on September 9th from 10am – 1pm ET
To view: http://videocast.nih.gov
10:00 a.m. to adjournment – This portion of the meeting is open to the Public.
This meeting will be videocast from 10:00 a.m. to 1:00 p.m.: http://videocast.nih.gov
10:00 to 10:30 a.m.
- Call to Order———————————————————— Dr. Richard Hodes
- Director’s Status Report
- Future Meeting Dates
- Consideration of Minutes from Last Meeting
10:30 to 10:45 a.m.
II. Report: Task Force on Minority Aging Research
Dr J Taylor Harden
10:45 to 11:45 a.m.
III. Report: Working Group on Program
Dr. Stephen Kritchevsky
11:45 to 12:00 p.m.
IV. A Word from Retiring Members
Dr. Richard Hodes
David Bennett, J Taylor Harden, David Holtzman, Stephen Kritchevsky, and Sue Peschin
V. Council Guest Speaker
Dr. Eliseo J. Pérez-Stable
Director, National Institute on Minority Health and Health Disparities “Health Disparities Challenges in Aging Research”
VI. Council Guest Speaker
Dr. Monica A. Driscoll
Professor, Department of Molecular Biology and Biochemistry Rutgers, the State University of New Jersey
“Neurons Put Out the Trash: A Novel Facet of Proteostasis and Mitochondrial Quality Control”
The NIH Inclusion Across Lifespan-II Workshop is happening TOMORROW, starting at 11am Eastern.
For more information, visit the IAL-II website; in addition, we’ve provided some key details and links below.
To participate tomorrow, click here: https://videocast.nih.gov/live.asp?live=38384&preview=1.
Pre-recorded overviews of topic areas from some of the workshop panel co-chairs here: https://go.usa.gov/xGqGE.
Here’s an overview of the topics that will be covered:
Topic Area 1: Inclusion/exclusion criteria
- Pediatric perspective — Florence Bourgeois, M.D., M.P.H., Harvard Medical School | Watch the Topic 1 pediatric perspective video
- Older adult perspective — Cynthia Boyd, M.D., Johns Hopkins University | Watch the Topic 1 older adult perspective video
The study population defined by the eligibility criteria should be representative of the population of people with the condition being studied. The inclusion and exclusion criteria should be objective and written in clear, concise language, and investigators should provide a scientific justification for each criterion. The co-chairs will discuss this topic with specific considerations for the pediatric and older adult perspectives.
Topic Area 2: Study design and metrics
- Jerry Gurwitz, M.D., University of Massachusetts Medical School
- Peter Peduzzi, Ph.D., Yale University School of Medicine
PLEASE NOTE: Topic area 2: Study design and metrics does not have pre-recorded videos to view.
The study design and metrics of a clinical trial should be constructed in a way to be more inclusive across all ages, using input from the entire study population. Here we will examine challenges that investigators face when designing studies and how these challenges can impact clinical trials.
Topic Area 3: Recruitment, enrollment, and retention
- Pediatric perspective — Michelle S. Hamstra, M.S., Cincinnati Children’s Hospital Medical Center |Watch the Topic 3 pediatric perspective video
- Older adult perspective — Steven Wallace, Ph.D., University of California, Los Angeles | Watch the Topic 3 older adult perspective video
Ensuring appropriate representation of children and older adults in clinical trials goes beyond the inclusion criteria — additional consideration is needed to design effective methods to identify, enroll, and retain children and older adults in clinical studies and trials. The co-chairs will examine the pediatric and geriatric considerations for recruitment and retention with emphasis on special populations.
Topic Area 4: Data analysis and study interpretation
- Pediatric perspective — Valentina Shakhnovich, M.D.,University of Missouri-Kansas City School of Medicine | Watch the Topic 4 pediatric perspective video.
- Older adult perspective — Heather Allore, Ph.D., Yale University School of Medicine | Watch the Topic 4 older adult perspective video.
Appropriate data analysis and interpretation is critical to the synthesis of trial evidence and its application in treating patients. This includes careful consideration of certain sub-populations in the analysis, including children and older adults. The study of specific sub-populations must be considered throughout the process, beginning with study design, and extending to data analysis, interpretation, and dissemination. With increases in inclusion of children and older adults in clinical studies, it is critical to develop data analysis plans that ensure appropriate, relevant, and meaningful study conclusions.