The NIA has funded a major study to examine the overall health benefits and risk of statins (cholesterol-lowering drugs) in adults age 75 or older without cardiovascular disease. The trial, called Pragmatic Evaluation of Events and Benefits of Lipid-Lowering in Older Adults (PREVENTABLE), will help determine whether a statin can help prevent dementia and disability in this age group, as well as heart attacks and other cardiovascular-related deaths, while not increasing risks of adverse health outcomes. The investigators plan to enroll 20,000 participants who will be randomly assigned to take either the statin atorvastatin or a placebo daily for up to five years.